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Xi'an Honson Biotechnology Co., Ltd. 1v1.biz

Country/Region:China
Province/State:Shaanxi
City:Xi'an
Street Address:Kanghong Industry District ,No. 40 Gaoxin 6Th Rd.
Zip:710075
Fax:86-29-88453169
Website:http://www.1v1.biz/company/xi-an-honson-biotechnology-co-ltd/200012521/
Contact Person:Mr. Sam Zhang
Telephone:86-29-88452005

Selected Products of Xi'an Honson Biotechnology Co., Ltd.

Physcion
Physcion CAS #: Molecular formula: Molecular weight: Formulation: Purity: 521-61-9 C16H12O5 284.26 White porwer 99% 1,8-Dihydroxyanthraquinones, present in laxatives, fungi imperfecti, Chinese herbs and possibly vegetables, are in debate as human carcinogens. We screened a variety of vegetables (cabbage lettuce, beans, peas), some herbs and herbal-flavoured liquors for their content of the 'free' anthraquinones emodin, chrysophanol and physcion. For qualitative and quantitative analysis, reversed-phase HPLC (RP-LC), gas chromatography-mass spectrometry (GC-MS) and RP-LC-MS were used. The vegetables showed a large batch-to-batch variability, from 0.04 to 3.6, 5.9 and 36 mg total anthraquinone per kg fresh weight in peas, cabbage lettuce, and beans, respectively. Physcion predominated in all vegetables. In the herbs grape vine leaves, couch grass root and plantain herb, anthraquinones were above the limit of detection. Contents ranged below 1 mg/kg (dry weight). All three anthraquinones were also found in seven of 11 herbal-flavoured liquors, in a range of 0.05 mg/kg to 7.6 mg/kg. The genotoxicity of the analysed anthraquinones was investigated in the comet assay, the micronucleus test and the mutation assay in mouse lymphoma L5178Y tk+/- cells. Emodin was genotoxic, whereas chrysophanol and physcion showed no effects. Complete vegetable extract on its own did not show any effect in the micronucleus test. A lettuce extract completely abolished the induction of micronuclei by the genotoxic anthraquinone danthron. Taking into consideration the measured concentrations of anthraquinones, estimated daily intakes, the genotoxic potency, as well as protective effects of the food matrix, the analysed constituents do not represent a high priority genotoxic risk in a balanced human diet.
Paclitaxel
Paclitaxel CAS #: Molecular formula: Molucular weight: Formulation: Purity: 16837-52-8 C15H24N202264.36 white crystalline powder 98%, 99% Paclitaxel is a natural substance derived from the yew tree by taking a naturally present substance from the tree and chemically altering it to form the drug. The resultant drug is administered intravenously. It is used as a chemotherapy drug to treat people with a wide variety of cancers.
Oleanolic Acid
Oleanolic acid CAS #: Molecular formula: Molecular weight: Formulation: Purity: C30H48O3 456.71 White needle crystal or powder 99% Oleanolic acid is a triterpenoid compound that is widespread in nature, in particular it occurs in leaves of Olea europea L. (Oleaceae). It has been long recognized to have hepatoprotective, antiinflammatory, and antihyperlipidemic properties. Recently oleanolic acid has been noted for its antitumor-promotion effect. Little is known about the antiviral activity of this compound. In this study the effect of oleanolic acid on the growth of HIV-1 in cultures of human peripheral blood mononuclear cells (PBMC) was investigated Both oleanolic acid and ursolic acid are effective in protecting against chemically induced liver injury in laboratory animals. Oleanolic acid has been marketed in China as an oral drug for human liver disorders. The mechanism of hepatoprotection by these two compounds may involve the inhibition of toxicant activation and the enhancement of the body defense systems. Oleanolic acid and ursolic acid have also been long-recognized to have antiinflammatory and antihyperlipidemic properties in laboratory animals, and more research is warranted to develop a therapy for patients. Recently, both compounds have been noted for their antitumor-promotion effects, which are stimulating additional research in this field. Oleanolic acid and ursolic acid are relatively non-toxic, and have been used in cosmetics and health products. The possible mechanisms for the pharmacological effects and the prospects for these two compounds are discussed.
Plant Extract
Our detailed management scope: First, to extract and separate the effective components from plants. The full set stainless steel equipment we used and advanced technology, plus our high-level production and management system will fully guarantee the plant extract quality. Second, to process Chinese herbal medicine. Continuous countercurrent extraction and spray drying can farthest preserve the active constituent of the herb, can also guarantee product appearance and internal quality, as well as to improve product fineness. Third, to process Semi-manufactured products. It can ensure success of Simi-manufactured production and large-scale natural plant production by perfect equipment and integrative technology. Fourth, to develop the new natural plant products. It includes to supply extraction and separation craft of plant effective components and to draft and revise drug quality criteria in new drug report. Fifth, to identify the quality of medical materials at the same time to guide Med Mat production and processing through effective component analysis. Management principle: Quality policy: to bring new ideas to technology
Plant/Herbal Extract
Our detailed management scope: First, to extract and separate the effective components from plants. The full set stainless steel equipment we used and advanced technology, plus our high-level production and management system will fully guarantee the plant extract quality. Second, to process Chinese herbal medicine. Continuous countercurrent extraction and spray drying can farthest preserve the active constituent of the herb, can also guarantee product appearance and internal quality, as well as to improve product fineness. Third, to process Semi-manufactured products. It can ensure success of Simi-manufactured production and large-scale natural plant production by perfect equipment and integrative technology. Fourth, to develop the new natural plant products. It includes to supply extraction and separation craft of plant effective components and to draft and revise drug quality criteria in new drug report. Fifth, to identify the quality of medical materials at the same time to guide Med Mat production and processing through effective component analysis. Management principle: Quality policy: to bring new ideas to technology
Resveratrol
Resveratrol CAS #: Molecular formula: Molucular weight: Formulation: Source: Purity: 501-36-0 C14H12O3228.24 white crystalline powder Polygonum cuspidatum 95%, 98%, 99% Resveratrol is an active component extracted from Huzhang(Polygonum cuspidatum) in China. It is an antioxidant phenol and a potent vasodilator that inhibits serum triglyceride synthesis, lipid peroxidation, and platelet aggregation. It is extensively used for treatment of blood vessel disease such as atherosclerosis and hyperlipidemia. In addition, it has anti-virus and anti-inflammatory activity, can treat acute microbial infections and viral hepatitis, ect.
Quercetin
Quercetin CAS #: Molecular formula: Molecular weight: Purity: 6151-25-3 C15H10O7 302.23 98% By HPLC Quercetin offers a variety of potential therapeutic uses, primarily in the prevention and treatment of the following conditions: Allergies, asthma, and hives: Quercetin may inhibit histamine release from basophils (a type of white blood cell) and mast cells (large cells in connective tissue). Canker sores: Quercetin may reduce the frequency of mouth sores and produce mild symptomatic relief. Heart disease: Individuals with very low intakes of flavonoids are at higher risk for heart disease. Infection: Quercetin may control the spread of certain viruses within the body. Rheumatoid arthritis: Quercetin may help reduce tissue destruction. Quercetin may also be beneficial in the treatment of dysentery (an intestinal infection causing severe diarrhea), gout (a disease where crystals of uric acid, a component of urine, are deposited in the joints and cause swelling), and psoriasis (a chronic skin disease).
Puerarin
Puerarin CAS #: Molecular formula: Molucular weight: Formulation: Source: Purity: 3681-99-0 C21H20O9416.38 White crystalline solid Pueraria lobata 98%, a kind of isoflavone compound extracted from roots of wild kudzu, Improve microcirculation,dilate coronary artery, increase blood stream volume of brain and coronary artery, reduce heart rate, reduce index of myocardial oxygen consumption as to inproce the metabolism of ischemic myocarduum.it also has functions of resisting thrombus, raising the high-density lipoprotein,resisting vasospasm, and reducing platelet aggregation.
Podophyllotoxin
Podophyllotoxin CAS #: Molecular formula: Molecular weight: Formulation: Purity: Solubility: 518-28-5 C22H22O8 414.41 White crystalline powder 98% Very soluble in Chloroform, soluble in methanol and ethanol, slightly soluble in ethyl ether. Almost insoluble in water. Podophyllotoxin is derived from the roots of podophyllum plant. It is applied directly to genital warts. When it penetrates the wart tissue, it has a toxic effect on the nuclei of the wart cells. The nucleus is the cell's control centre. It controls cell division and multiplication (mitosis). This results in the healthy growth of tissue. Podophyllotoxin is an antimitotic and by its action on the nuclei, prevents the wart cells from dividing. This stops the cells multiplying. Over time, all the wart cells die and new healthy tissue grows in their place.
Herbal Extract
Our detailed management scope: First, to extract and separate the effective components from plants. The full set stainless steel equipment we used and advanced technology, plus our high-level production and management system will fully guarantee the plant extract quality. Second, to process Chinese herbal medicine. Continuous countercurrent extraction and spray drying can farthest preserve the active constituent of the herb, can also guarantee product appearance and internal quality, as well as to improve product fineness. Third, to process Semi-manufactured products. It can ensure success of Simi-manufactured production and large-scale natural plant production by perfect equipment and integrative technology. Fourth, to develop the new natural plant products. It includes to supply extraction and separation craft of plant effective components and to draft and revise drug quality criteria in new drug report. Fifth, to identify the quality of medical materials at the same time to guide Med Mat production and processing through effective component analysis. Management principle: Quality policy: to bring new ideas to technology
Piperine
Name: Piperine Molecular Structure: Molecular formula: C17H19NO3 Molecular weight : 285.34 C.A.S#: 94-62-2 Melting point: 128-132°C Formulation: a pale yellow to yellow crystalline solid Purity: 98% Function and Usage: Piperine is often added to prepared food to enhance aroma and flavor.It can Promote drug absorption, and improve the effectiveness of the drug function. In clinical practice, it can induce calm (sedative effect) or to induce sleep (hypnotic effect), and used to make anticonvulsant, antidepressant, and muscle relaxation drug.
Silybin Extract
Silybin CAS #: Molecular formula: Molucular weight: Formulation: Purity: 22888-70-6 C25H22O10482.44 A crystalline solid 70%, 80%, 95%, 98% Silybin (silibinin) is the major flavonolignan from the extracts of milk thistle seed, Silybum marianum. The whole extract, known as silymarin, has been found to protect the liver from both acute and chronic toxicity and injury. Silybin blocks the production of superoxide in PMA-activated rat Kupffer cells with an EC50 of around 100 µM.1 Silybin also blocks the synthesis of leukotriene B4 by these same cells with an IC50 of about 15 µM. Thus, part of the protective effects of silybin could be due to 5-lipoxygenase inhibition.
Yohimbe Hcl
Yohimbe HCl CAS #: Molecular formula: Molecular weight: Purity: 146-48-5 C21H26O3 354.45 Yohimbine 1%--98% Test By HPLC Yohimbe is an evergreen tree that grows in western Africa in Nigeria, Cameroon, the Congo and Gabon. The bark of the tree contains the active compounds called alkaloids. The principal alkaloid is called yohimbine. Yohimbe has been one of the most popular supplements for men and women for years. When ingested, the body converts it to yohimbine and assimilates it into the bloodstream. Similar alkaloids also play a role. Bodybuilding.com's high alkaline herbal yohimbe is made from the finest sources in the world. What an awesome supplement! Its popularity has been ignited not only by it's claimed effects as an aphrodisiac and hallucinogen, but also new research that shows it could be an herb with very effective antioxidant potential. Research shows it is a vasodilator, which means that it increases blood flow to the extremities and appendages.
Usinic Acid
Usinic acid CAS #: Molecular formula: Molucular weight: Formulation: Purity: 7562- 61-0 C18H16O7344.32 yellow crystalline powder 98%, 99% Usnic acid is extracted from Usnea, Usnea, also known as old mans beard, is not a plant but a lichena symbiotic relationship between an algae and a fungus. The entire lichen is used medicinally. Usnea looks like long, fuzzy strings hanging from trees in the forests In natural remedies, especially in the veterinary medicine, Usnic Acid is used in powders and ointments for the treatment of infections of the skin. Usnic acid as a pure substance has been formulated in creams, toothpaste, mouthwash, deodorants and sunscreen products, in some cases as an active principle, in others as a preservative.
Synephrine
Synephrine CAS #: Molecular formula: Molecular weight: Synonyms Purity: 94-07-5 C9H13NO2 167.21 Sympathol, Oxedrine Synephrine 5%--98% Test By HPLC Synephrine is the main "active" compound found in the fruit of a plant called Citrus aurantium. The fruit is also known as zhi shi (in traditional Chinese medicine), and as green orange, sour orange and bitter orange in other parts of the world. It has strong aroma. It tastes bitter at first, and then a little acid. In application of traditional Chinese medical science, it is used to dispel bloating and a lump in the abdomen and phlegm, and to cureedema, constipation, gastroptosis, prolapse of uterus and rectocele. Anti- tumour, prevent osteoporosis, reduce cholesterin and protect heart. Nerve protection and prevent diseases of degeneration of nerve.Relieve menopausal symptoms of women, improve bone metabolism and protect cardiovascular system, etc.
Soybean Oligosaccharides
Name: Soybean oligosaccharides(SBOS) Synonyms: Lycoposes Molecular Structure: Molecular formula: C24H42O21·4H2O Molecular weight : 738.64 C.A.S number : 10094-58-3 Assay: Stachyose ≥50% Raffinose ≥14% Verbascose≥16% Characteristic: White powder,soluble in water. Function and Usage: Soybean oligosaccharides promote the growth of Bifidobacteria in the intestinal tract.It can increase the growth of Bifidobacterium which can safeguard health by protecting against infection from harmful bacteria, inhibit the production of intestinal putrefactive compounds, produce vitamins, enhance peristalsis of the intestines, stimulate the immune response, and decomposing carcinogens. So SBOS has the significant healthy effects on constipation, paralytic ileus and adjust intestinal ecological environment, inhibit harmful, prevent osteoporosis, promote vitamin synthesis, benefit of keeping youth.
Sinomenine Hcl
Sinomenine HCL CAS #: Molecular formula: Molecular weight: Appearance:: Purity: 115-53-7 C19H23NO4 329.38 White powder 98% By HPLC Sinamenine HCL is now known to be effective in neuralgia and rheumatic diseases. sinomenine is a unique plant alkaloid, as it potently releases histamine in association with degranulation of mast cells in connective tissue, preferentially in the skin and joint capsules. the released histamine is responsible for the pharmacological actions of sinomenine, such as vasodilation, increased vascular permeability, acceleration of the thoracic and peripheral lymph flow, contraction of smooth muscles, increased peristalsis of the intestines, and stimulation of gastric acid secretion
Shikimic Acid
Shikimic acid CAS #: Molecular formula: Molucular weight: Formulation: Source: Purity: 138-59-0 C7H10O5174.15 white crystalline powder Illicium Verum Hook. f. 98% Shikimic Acid is an active ingrediets which is extracted from Illicium verum Hook. f. , Shikimic Acid is a key precursor of many alkaloids, aromatic amino acids, indole derivatives, and it also be widely used as a chiral building block for the synthesis of pharmaceuticals. Now, Shikimic Acid serves as the starting material for Oseltamivir which is a neuraminidase inhibitor used in the treatment and prophylaxis of both influenza A and influenza B.
Rutin
Rutin CAS #: Molecular formula: Molecular weight: Formulation: Purity: 153-18-4 C27H30O16 610.53 pale yellow solid 99% Rutin is a phenolic antioxidant and has been demonstrated to scavenge superoxide radicals. Rutin can chelate metal ions, such as ferrous cations. Ferrous cations are involved in the so-called Fenton reaction, which generates reactive oxygen species. Rutin may also modulate the respiratory burst of neutrophils. The in vivo antioxidant activity of rutin is most likely due to its aglycone quercetin, to which it is metabolized following ingestion. Although most studies show rutin to inhibit lipid peroxidation, a few studies do not. Rutin may also help maintain levels of the biological antioxidant reduced glutathione. Importantly, under certain conditions, rutin or its metabolite quercetin may become a pro-oxidant. For example, nitrosation of rutin/ quercetin may produce a pro-oxidant molecule that may have mutagenic potential.
Rhein
Rhein CAS #: Molecular formula: Molecular weight: Formulation: Purity: 478-43-3 C15H8O6 284.21 White powder 99%
Lutein
lutein CAS #: Molecular formula: Molecular weight: Formulation: Purity: 127-40-2 C40H56O2 568.88 orange to red crystalline powder 10%, 20%, 40%, 50%, 90% Lutein is a carotenoid, meaning a natural colorant or pigment, found in dark green leafy vegetables such as spinach, plus various fruits and corn. Egg yolks are also sources of lutein. Lutein provides nutritional support to our eyes and skin the only organs of the body directly exposed to the outside environment. Lutein has been linked to promoting healthy eyes through reducing the risk of macular degeneration. Other studies suggest that a mixture of nutrients, including lutein, may provide supplemental antioxidant capacity to the skin, helping counteract free radical damage. Lutein also filters the high-energy, blue wavelengths of light from the visible-light spectrum by as much as 90%. Blue light, in both indoor lighting and sunlight, is believed to induce oxidative stress and possible free-radical damage in human organs exposed to light, such as the eyes and skin. Blue light is not the same as the commonly known ultraviolet A and ultraviolet B wavelengths of the invisible spectrum.
Biotin (Vitamin H)
Biotin (vitamin H) CAS#: 58-85-5 Molecular Structure: Molecular Formula: C10H16N2O3S Molecular Weight:244.31 Quality Standard: USP30 Biotin contains not less than 97.5 percent and not more than percent of C10H16N2O3S. Characteristic: Usage And Functions:
Ursolic Acid
Name: Ursolic acid Molecular Structure: Molecular formula: C30H48O3 Molecular weight : 456.68 C.A.S number : 77-52-1 Formulation: White powder Purity: 98% Melting Point: 277∼278 Function and Usage: Ursolic acid has many medical effects such as anti-cancer, anti-bacterial, anti-inflammatory, lowering serum transaminase, cooling and stability, etc.; can be used as drugs, food emulsifier; Latest experiments proved that ursolic acid has remarkable anti-diabetic effect.
Troxerutin
Troxerutin CAS #: Molecular formula: Molecular weight: Formulation: Purity: 7085-55-4 C33H42O19 742.68 Light yellow. or brown powder 99% troxerutin, a trihydroxy-ethyl-rutoside, in the venous wall have been studied in patients undergoing long saphenous vein surgery. Troxerutin, an autofluorescent drug, is currently used to relieve oedema and subjective symptoms in patients with chronic venous insufficiency. In order to determine the localization of the troxerutin, a confocal scanning laser microscope has been used to record the fluorescence from vein cross sections. The quantified fluorescence was used as a measure of the local concentration of troxerutin. In order to reduce the effects of local variation, several images have been scanned from each specimen. Then the recorded data have been analysed to see how the fluorescence varies in the radial direction within the venous wall. Results showed that troxerutin was significantly accumulated in both inner and outer parts of the venous wall. Whereas inner wall troxerutin uptake resulted from direct diffusion through the lumen, the outer wall uptake proceeded likely from the vasa vasorum circulation.
Solanesol
Solanesol CAS #: Molecular formula: Molucular weight: Formulation: Purity: 13190-97-1 C45H74O 631.07 light yellow white crystalline powder 90% Solanesol is extracted from tobacco, it's the starting material for many high-value bio-chemicals as vitamin-K analogues and coenzyme Q10. It is also a potentiating agent in these medicines. The research showes that after introducing "solanesol" radical into the structure of some medicines, the effect are increased distinctly. With solenesol as its primary material, Co-enzyme Q is useful in the treatment of heart diseases, cancers and ulcers
Salicin
Salicin CAS #: Molecular formula: Molecular weight: Purity: 138-52-3 C13H18O7 286.29 Salicin 15% 25% 98% Test By HPLC Salicin safely be taken long-term at recommended doses. Higher than commonly recommended doses of this herb can cause stomach upset, nausea, or tinnitus (ringing in the ears). If any of these reactions develop. Stop taking the herb. Avoid white willow bark, which can irritate the stomach, if you are sensitive to aspirin, or if you have an ulcer or other gastrointestinal disorder. As with aspirin products, never give white willow bark to children or teenagers under age 16 with symptoms of the cold, the flu, or chicken pox. Although white willow bark is unlikely to cause the rare but potentially fatal condition called Reyes syndrome in such casesit is metabolized differently than aspirinthe similarity to aspirin is close enough to warrant caution.
Alpha Lipoic Acid
Name: Alpha Lipoic Acid Synonyms: DL-alpha-Lipoic acid; DL-6,8-Dithiooctanoic acid; 5-(Dithiolan-3-yl)valeric acid C.A.S #: 1077-28-7 Molecular Structure: Molecular formula: C8H14O2S2 Molecular weight : 206.33 Assay: 99.0-101.0% Quality Standards: USP30 Alpha-Lipoic acid contains not less than 99.0 percent and not more than 101.0 percent of C8H14O2S2,calculated on the dried basis. Characteristic: Yellow crystalline powder, almost tasteless. Melting point: 58-63°C Boiling point: 160-165°C Water solubility: Soluble in benzene, ethanol, ethyl ether, chloroform and other organic solvents, but also soluble in water. Function and Usage: -lipoic acid is a vitamin drugs, limited physical activity in its dextral (), basically no physical activity in its L - Lipoic acid (), and no side effects. It is always used for acute and chronic hepatitis, liver cirrhosis, hepatic coma, fatty liver, diabetes, Alzheimer's disease ,and applies as an antioxidant health products.
Vitamin K2 (20)
Name: Vitamin K2(20) Synonyms: Vitamin K2, Vitamin MK4,menaquinone Molecular Structure: Molecular formula: C31H40O2 Molecular weight : 444.65 C.A.S number : 863-61-6 Assay: 98% Characteristic: Function and Usage: Vitamin K2 is a fat-soluble vitamin,it is needed to manufacture prothrombin, a substance essential for the normal clotting of blood. 1.Vitamin K2 is being used to cure haemorrhage caused by VK2 deficiency; promotes the formation of thrombin, accelerates blood clotting, maintains proper clotting time; also used as quick coagulant in surgeries or first aids 2. Vitamin K2 is being used to treat the degenerative bone disease osteoporosis.; VK2 produces a specific protein known as osteocalcin which can bind calcium, therefore to increase the density of bones and to prevent fracture. 3. Vitamin K2 can prevent the disease of hepatocellular carcinoma in women with viral cirrhosis. 4. Vitamin K2 has function of diuresis, promotes the detoxifcation of liver and lowering the blood pressure.
Panthenol
Name: Panthenol Synonyms: DL-Panthenol; (+/-)-2,4-Dihydroxy-3,3-dimethylbutyric 3-hydroxypropylamide C.A.S # : 16485-10-2 Molecular Structure: Molecular formula: C9H19NO4 Molecular weight : 205.25 Assay: 97.0-102.0% Quality Standards: USP30 Panthenol contains not less than 99.0 percent and not more than 102.0 percent of C9H19NO4,calculated on the anhydrous basis. Characteristic: Hygroscopicity white crystalline powder Melting point: 66-69°C Water solubility: Well soluble in water, alcohol and propylene glycol, soluble in ether and chloroform, and slightly soluble in glycerin. Function and Usage: In cosmetics, panthenol is a humectant, emollient and moisturizer. It binds to hair follicles readily and is a frequent component of shampoos and hair conditioners (in concentrations of 0.1-1%). It coats the hair and seals its surface, lubricating follicles and making strands appear shiny. In ointments it is mixed with allantoin, in concentrations of up to 2-5%, and is used for treatment of sunburns, mild burns and minor skin disorders.
Cholecalciferol
Name: Cholecalciferol C.A.S #: 67-97-0 Synonyms: 9,10-Secocholesta-5,7,10(19)-trien-3beta-ol; Cholecalciferol Molecular Structure: Molecular formula: C27H44O Molecular weight : 384.64 Assay: 97.0-103.0% Quality Standards: USP30 Cholecalciferol contains not less than 97.0 percent and not more than 103.0 percent of C27H44O. Characteristic: Colorless crystal powder. Melting point: 82-87°C Alpha: 105° (c=0.8, EtOH 25°C) Water solubility: Soluble in alcohol, ether, acetone, chloroform and vegetable oil, and do not dissolve in water. Function and Usage: Cholecalciferol reduces calcium loss from bones and increases the production of normal healthy bone in patients with osteoporosis.
Topotecan Hcl
Topotecan HCl CAS #: Molecular formula: Molecular weight: Purity: 119413-54-6 C23H23N3O5.HCl 457.91 98% By HPLC Topotecan, a semi-synthetic derivative of camptothecin (a plant alkaloid obtained from the Camptotheca acuminata tree), is an anti-tumor drug with topoisomerase I-inhibitory activity similar to irinotecan. Topotecan interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal cells may also be affected by the medicine, other effects may also occur. Unlike irinotecan, topotecan is found predominantly in the inactive carboxylate form at neutral pH and it is not a prodrug. Topotecan has the same mechanism of action as irinotecan. Topoisomerase I relieves torsional strain in DNA by inducing reversible single strand breaks. Topotecan binds to the topoisomerase I-DNA complex and prevents religation of these single strand breaks. The cytotoxicity of topotecan is thought to be due to double strand DNA damage produced during DNA synthesis when replication enzymes interact with the ternary complex formed by topotecan, topoisomerase I and DNA. Mammalian cells cannot efficiently repair these double strand breaks.
Etidronate Sodium
Etidronate sodium CAS #: Molecular formula: Molecular weight: Purity: 7414-83-7 C2H6Na2O7P2 249.99 98% By HPLC Sodium etidronate is a diphosphonate compound that inhibits bone resorption and mineralization. The drug has been reported to be highly effective for the palliation of painful bone metastasis from prostatic cancer. Fifty-seven patients were entered into a randomized, prospective, double-blind, placebo-controlled study of sodium etidronate. All patients had hormone refractory metastatic prostatic cancer and bone pain requiring analgesics. No difference was seen in the symptomatic response rate or analgesic requirement between patients treated with sodium etidronate and placebo. With the dose scheme used in this study sodium etidronate was ineffective for palliation of bone pain from prostatic cancer.

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